DEGRADASI POLIBLEND POLI(ASAMLAKTAT-KO-ASAMGLIKOLAT) DENGAN POLI(ε-KAPROLAKTON) SECARA IN VITRO

Authors

  • Tetty Kemala
  • Achmad Sjahriza
  • Hendra Adijuwana
  • Mardiana Hardianti

DOI:

https://doi.org/10.25077/jrk.v2i2.158

Abstract

 

ABSTRACT

 

 

Polymer has many applications in human life, one of them is in the field of health. Polymer synthetics like polylactic acid (PLA), polyglycolic acid (PGA), poly(ε-caprolactone) (PCL), and poly(lactic acid-co-glycolic acid) (PLGA) were kind of polyesters that is many used in field   of health. Many researchers have already made research about degradation of PLA, PGA, PCL, and PLGA. However, there is no one doing research about degradation of combination between this two polymers, one of them is polyblend of  PLGA and PCL. Polyblend were made of four compositions, that were PLGA(90:10):PCL 3:1, PLGA(75:25):PCL 3:1, PLGA(90:10):PCL 5:1, and PLGA(75:25):PCL 5:1. Degradation was carried out for eight weeks by using phosphate buffer pH 7.4 and incubation temperature of 37°C. Degradation of the polymer was observed by mass remained, and intrinsic viscosity. The result showed that composition PLGA(75:25):PCL 5:1 was the fastest in degradation compared to other compositions. It was showed by the decrease in mass until 89.06% and the change in intrinsic viscosity until 20.13%.

 

Keywords: PLGA, PCL

   

Author Biographies

Tetty Kemala

   

Achmad Sjahriza

   

Hendra Adijuwana

   

Mardiana Hardianti

   

References

A, Porjazoska, et al., Synthesis and characterization of biocompatible multicomponent polymer systems as supports for cell cultures. Buletin of the chemists & tecnologiest of Macedonia, 23: 147-156, (2004).

R. Sujatmiko, Pencirian poliblend kopolimer poli(asamlaktat)-poli(asamglikolat) dengan poli(ε-kaprolakton), Bogor, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, 2007.

Kiretmici-Gumusdereliouglu, G. Deniz, Synthesis, characterization and in vitro degradation of poly(d,l-lactide)/poly(d,l-lactide-co-glycolide) films, Turk. J. Chem., 23: 153-161, (1999).

S. Matsumura, Mechanism of biodegradation, Biodegradable Polymers for Industrial Applications, Smith R, England, Woodhead Publishing, , 2005,357-361, 365-369..

P. A. Gunatillake, A. Raju,. Biodegradable synthetic polymers for tissue enginerring, Eur Cells and Materials, 5: 1-16, (2003)

S. J. Huang, P. G. Edelman, An overview of biodegradable of polymer, Degradable Polymers: Principles & Applications, Scott G, Dan G, London: Chapman & Hall, 1995,18-19.

Bhattacharya, R. L. Reis, V. Correlo, L. Boesel, Material properties of biodegradable polymers, Biodegradable Polymers for Industrial Applications, R. Smith, Woodhead Publishing, England, 2005, 343-345.

Porjazoska A et al.,. Poly(lactide-co-glycolide) microparticles as system for controlled release of protein-preparation and characterization, Acta Pharm., 54: 215-229, (2004a)

U. Edlund, A. C. Albertson, Degradable Polymer Microsphere for Controlled Drug Delivery, Degradable Aliphatic Polyesters, Albertson A. C, New York, Springer, 2002, 70-85.

D. M. Billings, Lippincott’s Review for NCLEX-RN, Philladelphia, Lippincott Williams & Wilkins, 2005.

Saladin, Human Anatomy, New York, McGraw, 2005

T. D. Farahani, A. A. Entezami, H. Mobedi, M. Abtahi, Degradation of poly(d,l-lactide-co-glycolide) 50:50 implant in aqueous Medium. Iranian Polym. J., 14: 753-763. (2005).

Downloads

Published

2015-02-12

How to Cite

Kemala, T., Sjahriza, A., Adijuwana, H., & Hardianti, M. (2015). DEGRADASI POLIBLEND POLI(ASAMLAKTAT-KO-ASAMGLIKOLAT) DENGAN POLI(ε-KAPROLAKTON) SECARA IN VITRO. Jurnal Riset Kimia, 2(2), 174. https://doi.org/10.25077/jrk.v2i2.158

Issue

Vol. 2 No. 2 (2009): March

Section

Articles

Citation Check

License

Please find the rights and licenses in Jurnal Riset Kimia (J. Ris. Kim). By submitting the article/manuscript of the article, the author(s) agree with this policy. No specific document sign-off is required.

1. License

The use the article will be governed by the Creative Commons Attribution license as currently displayed on Creative Commons Attribution 4.0 International License. 

2. Author(s)' Warranties

The author warrants that the article is original, written by stated author(s), has not been published before, contains no unlawful statements, does not infringe the rights of others, is subject to copyright that is vested exclusively in the author and free of any third party rights, and that any necessary written permissions to quote from other sources have been obtained by the author(s).

3. User Rights

Under the Creative Commons license, the journal permits users to copy, distribute, and display the material for any purpose. Users will also need to attribute authors and J. Ris. Kim on distributing works in the journal and other media of publications.

4. Rights of Authors

Authors retain all their rights to the published works, such as (but not limited to) the following rights;

  • Copyright and other proprietary rights relating to the article, such as patent rights,
  • The right to use the substance of the article in own future works, including lectures and books,
  • The right to reproduce the article for own purposes,
  • The right to self-archive the article,
  • The right to enter into separate, additional contractual arrangements for the non-exclusive distribution of the article's published version (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

5. Co-Authorship

If the article was jointly prepared by more than one author, any authors submitting the manuscript warrants that he/she has been authorized by all co-authors to be agreed on this copyright and license notice (agreement) on their behalf, and agrees to inform his/her co-authors of the terms of this policy. J. Ris. Kim will not be held liable for anything that may arise due to the author(s) internal dispute. J. Ris. Kim will only communicate with the corresponding author.