KINETIKA PERMEASI KLOTRIMAZOL DARI MATRIKS BASIS KRIM YANG MENGANDUNG VIRGIN COCONUT OIL (VCO)
AÂ kineticÂ studyÂ onÂ theÂ releaseÂ ofÂ clotrimazoleÂ fromÂ aÂ VCOÂ containingÂ creambaseÂ hasÂ beenÂ undertaken.Â TheÂ in-vitroÂ releaseÂ ofÂ theÂ drugÂ wasÂ studiedÂ byÂ usingÂ aÂ modificationÂ diffusionÂ cellÂ apparatus.Â FourÂ formulationsÂ ofÂ clotrimazoleÂ creamÂ wereÂ prepared,Â eachÂ containedÂ eitherÂ VCOÂ orÂ paraffinÂ liquidumÂ inÂ theÂ creamÂ base.Â TheÂ amountÂ ofÂ clotrimazoleÂ releaseÂ wereÂ determinedÂ byÂ UVÂ spectrophotometer.Â ResultsÂ showedÂ thatÂ releaseÂ ofÂ clotrimazoleÂ fromÂ allÂ formulationsÂ followedÂ HiguchiÂ kinetics,Â theÂ releaseÂ rateÂ constantÂ fromÂ F1Â (containingÂ VCO)Â wasÂ significantlyÂ differentÂ thanÂ thatÂ fromÂ F1â€™Â (containingÂ paraffinÂ liquidum)Â (pÂ <Â 0.05).Â TheÂ rateÂ constantÂ ofÂ clotrimazoleÂ fromÂ F2Â (containingÂ VCO);Â F2â€™Â (containingÂ paraffinÂ liquidumÂ )Â andÂ F1Â wereÂ notÂ significantlyÂ different.Â VirginÂ coconutÂ oilÂ (VCO)Â wasÂ aÂ potentialÂ creamÂ baseÂ matrixÂ regardingÂ theÂ releaseÂ profileÂ ofÂ clotrimazoleÂ fromÂ theÂ matrix.
KeywordsÂ :Â clotrimazol,Â VCO,Â permeationÂ kinetic
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