Karakterisasi Struktur Kumarin pada Akar Tumbuhan Langsat (Lansium domesticum Corr.)

Authors

  • Riska Nurapita Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Tanjungpura, Indonesia
  • Rudiyansyah Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Tanjungpura, Indonesia
  • Harlia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Tanjungpura, Indonesia

DOI:

https://doi.org/10.25077/jrk.v15i1.610

Keywords:

Coumarin, iso-scopoletin, Lansium domesticum, phenolic

Abstract

Lansium plants produce not only terpenoids as the main constituent but also contain phenolics on the basis of phytochemical analysis. Unfortunately, there are still limited information about phenolic structures from this plants. This study was conducted to identify one of phenolic structures from chloroform fraction of Lansium domesticum root. The chloroform fraction was fractionated and purified by chromatographic techniques such as vacuum liquid chromatography (VLC) and column chromatography (CC) to obtain a coumarin. Additionally, the coumarin structure was characterized by 1H-NMR. The isolated coumarin showed a positive result for the phenolic test with FeCl3 5%. The 1H-NMR spectrum of isolated coumarin revealed chemical shifts at δH 7,60 (1H, d, J = 9,5 Hz), 6,92 (1H, s), 6,84 (1H, s), 6,27 (1H, d, J = 9,5 Hz), 6,14 (1H, s), and 3,95 (3H, s). Based on those results and comparison with literature data, it can be concluded that the isolated coumarin is iso-scopoletin (1)

References

Christenhusz, M. J. M., & Byng, J. W., The number of known plants species in the world and its annual increase. Phytotaxa, 261: 201-217 (2016).

Lim, T. K., Edible medicinal and non medicinal plants. 3th Vol: Fruits. Springer. New York (2012).

Naito, Y., Medicinal herb index in Indonesia. 2nd ed: PT. Eisai Indonesia (1995).

Loekitowati, H. P., & Hermansyah, H., Studi pemanfaatan biji duku (Lansium domesticum) untuk obat diare secara in vitro. JPS, 7: 41-48 (2000).

Worang, R. L., Samuel, M. Y., Pendong, D. F., Antimalarial and antibacterial bioactivity of langsat (Lansium minahasae L.) bark extract. Journal of Natural Sciences Research, 3(14): 1-11 (2013).

Kulip, J., An ethnobotanical survey of medicinal and other useful plants of Muruts in Sabah, Malaysia. Telopea, 10(1): 81-98 (2003).

Monzon, R. B., Alvior, J. P., Luczon, L. L. C., Morales, A. S., & Mutuc, R. E., Larvicidal potential of five Philippines plants against Aedes aegypti (Linnaeus) and Culex quinquefasciatus (Say). Southeast Asian J. Trop. Med. Public Health, 25(4): 755-759 (1994).

Korompis, G. E. C., Danes, V. R., & Sumampouw, O. J., Uji invitro aktivitas antibakteri dari Lansium domesticum Correa (Langsat). Chem. Prog., 3(1): 13-19 (2010).

Triadi, R., Rudiyansyah, R., & Alimuddin, A. H., Karakterisasi struktur triterpenoid dari akar tanaman langsat (Lansium domesticum). IJoPAC, 4(1): 40-50 (2021).

Yunus, I., Boddhi, W., & Queljoe, E. D., Skrining fitokimia dan uji toksisitas ekstrak Etanol daun langsat (Lansium Domesticum Corr.) terhadap larva Artemia salina Leach dengan metode brine shrimp lethality test (BSLT). Pharmacon, 7(3): 89-96 (2018).

Yamin, Y., Ruslin, R., Sabarudin, S., Sida, N. A., Kasmawati, H., & Diman, L. O. M., Determination of antiradical activity, total phenolic, and total flavonoid contents of extracts and fractions of Langsat (Lansium domesticum Corr.) seeds. Borneo J. Pharm., 3(4): 249-256 (2020).

Nur, S., Rumiyati, & Lukitaningsih, E. Skrining aktivitas antioksidan, antiaging dan penghambatan tyrosine dari ekstrak etanol dan etil asetat daging buah dan kulit buah langsat (Lansium domesticum Corr) secara in vitro. Trad. Med. J., 22(1): 63-72 (2017).

Abdallah, H. M., Mohamed, G. A., & Ibrahim, S. R. M., Lansium domesticum-A fruit with multi-benefits: Traditional uses, phytochemicals, nutritional value, and bioactivities. Nutrients, 14: 1531 (2022).

Shi, W., Hu, J., Bao. N., Li, D., Chen, L., & Sun, J., Design, synthesis and cytotoxic activities of scopoletin-isoxazole and scopoletin-pyrazole hybrids. Bioorganic Med. Chem. Lett., 27(2): 147-151 (2017).

Kemayou, G. P. M., Happi, G. M., Ngandjui, Y. A. T., Tchouankeu, J. C., Sewald, N., Ali, M. S., & Kouam, S. F., Senegalin, a new phenylpropanoid and other secondary metabolites from the stem bark Ekerbergia senegalensis A. Juss. (Meliaceae). Nat. Prod. Res., 35(21): 3694-3700 (2020).

Sielinou, V. T., Vardamides, J. C., Ali, M. S., Hameed, A. A., & Nkengfack, A. E., A new bis-labdane and other secondary metabolites from Turraeanthus mannii. Chem. Nat. Compd., 51(6): 1114-1119 (2015).

Liu, Y. B., Cheng, X. R., Qin, J. J., Yan, S. K., Jin, H. Z., & Zhang, W. D., Chemical constituents of Toona ciliata var. pubescens. Chin. J. Nat. Med., 9(2): 115-119 (2011).

Dong, X. J., Zhu, Y. F., Bao, G. H., Hu, F. L., & Qin, G. W., New limonoids and a dihydrobenzofuran norlignan from the roots of Toona sinensis. Molecules, 18(3): 2840-2850 (2013).

Katja, D. G., Sonda, A. A., Huspa, D. H. P., Mayanti, T., & Supratman, U., 7-Hidroksi-6-metoksi kumarin (skopoletin) dari kulit batang Chisocheton celebius (Meliaceae). J. Chem., 9(2): 267-270 (2015).

Mayanti, T., Wahyuni, A., Indriyani, I., Darwati, D., Herlina, T., & Supratman, U., Senyawa-senyawa aromatik dari ekstrak daun dan kulit batang Dysoxylum parasiticum serta toksisitasnya terhadap Artemia salina. Chimica et Natura Acta, 5(1): 26-30 (2017).

Tsamo, A. T., Melong, R., Mkounga, P., & Nkengfack, A. E., Rubescins I and J, further limonoid derivatives from the stem bark of Trichilia rubescens (Meliaceae). Nat. Prod. Res., 33(2): 196-203 (2019).

Harborne, J. B., Phytochemical analysis: A guide to modern techniques of plant analysis. 3rd ed: Chapman & Hall (1998).

Fitriana, F., & Prabawati, S. Y., Sintesis senyawa 3-asetil-7-(hidroksi) kumarin dan aktivitasnya terhadap bakteri Staphylococcus aureus dan Shigella flexneri. Indones. J. Mater. Chem., 1(1): 9-13 (2018).

Zhao, D. D., Zhao, Q. S., Liu, L., Chen, Z. Q., Zeng, W. N., Lei, H., & Zhang, Y. L. Compounds from Dryopteris Fragrans (L.) Schott with cytotoxic activity. Molecules, 19(3): 3345-3355 (2014).

Ragasa, C. Y., Tan, M. C. S., Fortin, D. R., & Shen, C. C., Chemical constituents of Ixora philippinensis Merr. J. App. Pharm. Sci., 5(9): 062-067 (2015).

Liang, Y., Zeng, X., Guo, J., Liu, H., He, B., Lai, R., Zhu, Q., & Zheng, Z., Scopoletin and umbelliferone from cortex mori as protective agents in high glucose-induced mesangial cell as in vitro model of diabetic glomerulosclerosis. Chin. J. Physiol., 64(3): 150-158 (2021).

Razavi, S. M., Nazemiyeh, H., Hajiboland, R., Yashodharan, K., Delazar, A., Nahar, L., & Sarker, S. D., Coumarins from the aerial parts of Prangos uloptera (Apiaceae). Rev. Bras. Farmacogn. Braz. J. Pharmacogn., 18(1): 1-5 (2008).

Downloads

Published

2024-03-29

How to Cite

Nurapita, R., Rudiyansyah, & Harlia. (2024). Karakterisasi Struktur Kumarin pada Akar Tumbuhan Langsat (Lansium domesticum Corr.). Jurnal Riset Kimia, 15(1), 1–7. https://doi.org/10.25077/jrk.v15i1.610

Issue

Vol. 15 No. 1 (2024): March

Section

Articles

Citation Check

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Please find the rights and licenses in Jurnal Riset Kimia (J. Ris. Kim). By submitting the article/manuscript of the article, the author(s) agree with this policy. No specific document sign-off is required.

1. License

The use the article will be governed by the Creative Commons Attribution license as currently displayed on Creative Commons Attribution 4.0 International License. 

2. Author(s)' Warranties

The author warrants that the article is original, written by stated author(s), has not been published before, contains no unlawful statements, does not infringe the rights of others, is subject to copyright that is vested exclusively in the author and free of any third party rights, and that any necessary written permissions to quote from other sources have been obtained by the author(s).

3. User Rights

Under the Creative Commons license, the journal permits users to copy, distribute, and display the material for any purpose. Users will also need to attribute authors and J. Ris. Kim on distributing works in the journal and other media of publications.

4. Rights of Authors

Authors retain all their rights to the published works, such as (but not limited to) the following rights;

  • Copyright and other proprietary rights relating to the article, such as patent rights,
  • The right to use the substance of the article in own future works, including lectures and books,
  • The right to reproduce the article for own purposes,
  • The right to self-archive the article,
  • The right to enter into separate, additional contractual arrangements for the non-exclusive distribution of the article's published version (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

5. Co-Authorship

If the article was jointly prepared by more than one author, any authors submitting the manuscript warrants that he/she has been authorized by all co-authors to be agreed on this copyright and license notice (agreement) on their behalf, and agrees to inform his/her co-authors of the terms of this policy. J. Ris. Kim will not be held liable for anything that may arise due to the author(s) internal dispute. J. Ris. Kim will only communicate with the corresponding author.